⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14403079 | 0.78 | — | — | |
| SCHEMBL10032968 | 0.77 | — | — | |
| SCHEMBL8213665 | 0.75 | MGAM (0.43) | — | |
| SCHEMBL835832 | 0.75 | — | — | |
| SCHEMBL6226292 | 0.73 | — | — | |
| SCHEMBL13955375 | 0.71 | TSHR (0.52) | — | |
| SCHEMBL24302489 | 0.71 | — | — | |
| SCHEMBL13983442 | 0.71 | — | — | |
| SCHEMBL6548521 | 0.71 | — | — | |
| SCHEMBL12285397 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353575-A1 | SEMICONDUCTING POLYMERS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-12-10 | — | — | US | disclosed |
| US-8937075-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-01-20 | — | — | US | disclosed |
| US-8927555-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-01-06 | — | — | US | disclosed |
| US-8445482-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-21 | — | — | US | disclosed |
| US-8440654-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-14 | — | — | US | disclosed |