Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870103 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL17347037 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL14269196 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL13202685 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL13870610 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL18543369 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL14269193 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL12894228 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL2888640 | 1.00 | TDP1 (0.47) | TDP1SIGMAR1EPHX2HRH4DPP4 | |
| SCHEMBL14289419 | 0.83 | TDP1 (0.39) | TDP1SIGMAR1EPHX2HRH4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440666-B2 | Pyridazinone compounds and P2X7 receptor inhibitors | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-05-14 | — | — | US | disclosed |