Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88124 | 0.91 | CCNE2 (0.38) | BRAF | |
| SCHEMBL88123 | 0.91 | CCNE2 (0.38) | BRAF | |
| SCHEMBL68826 | 0.88 | BRAF (0.34) | BRAF | |
| SCHEMBL68825 | 0.88 | BRAF (0.34) | BRAF | |
| SCHEMBL1494534 | 0.86 | BRAF (0.37) | BRAF | |
| SCHEMBL1494615 | 0.85 | BRAF (0.36) | BRAF | |
| SCHEMBL1494703 | 0.84 | BRAF (0.36) | BRAF | |
| SCHEMBL6521889 | 0.80 | BRAF (0.38) | BRAF | |
| SCHEMBL6521886 | 0.80 | BRAF (0.38) | BRAF | |
| SCHEMBL6521852 | 0.79 | CCNE2 (0.38) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470528-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | Novartis AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023773-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |