Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.81 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13972116 | 0.91 | PIK3CG (0.70) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL684664 | 0.89 | PIK3CG (0.76) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL1639483 | 0.89 | PIK3CG (0.76) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL1639481 | 0.89 | PIK3CG (0.76) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL1638504 | 0.86 | NTRK1 (1.00) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL1638502 | 0.86 | NTRK1 (1.00) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL12766909 | 0.86 | NTRK1 (1.00) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL683909 | 0.85 | PIK3CG (0.66) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL414436 | 0.84 | MEN1 (1.00) | PIK3CGNTRK1KMT2AMEN1KDM4E | |
| SCHEMBL1173698 | 0.84 | MEN1 (1.00) | PIK3CGNTRK1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029403-B2 | Treatment of ovarian cancer with benzylidenebenzohydrazides | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140315959-A1 | TREATMENT OF OVARIAN CANCER WITH BENZYLIDENEBENZOHYDRAZIDES | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2014-10-23 | — | — | US | disclosed |
| WO-2013071001-A1 | TREATMENT OF OVARIAN CANCER WITH BENZYLIDENEBENZOHYDRAZIDES | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315959-A1 | TREATMENT OF OVARIAN CANCER WITH BENZYLIDENEBENZOHYDRAZIDES | BRDT, BAX, BCL2 | PIK3CG 4720/4885NTRK1 4558/4885KMT2A 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.