Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949289

SCHEMBL14949289

SCHEMBL14949289

CSc1nc(N)cc(Oc2ccc(-c3nnc(Nc4cccc(C(C)(C)C)c4)[nH]3)cc2)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 4/20 0.61
▸ KIT P10721 4/20 0.61
▸ PDGFRA P16234 1/20 0.61
▸ CDK11B P21127 1/20 0.61
▸ FLT3 P36888 1/20 0.61
▸ CDKL2 Q92772 1/20 0.61
▸ BRAF P15056 13/20 0.38
▸ RAF1 P04049 6/20 0.38
▸ CYP3A4 P08684 3/20 0.35
▸ MEN1 O00255 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ KDR P35968 6/20 0.34
▸ LCK P06239 3/20 0.34
▸ FYN P06241 3/20 0.34
▸ FLT1 P17948 3/20 0.34
▸ FLT4 P35916 3/20 0.34
▸ MAPK14 Q16539 2/20 0.33
▸ TNNI3K Q59H18 2/20 0.33
▸ LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL625598 0.92 PDGFRB (0.73) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336481 0.91 PDGFRB (0.57) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336289 0.89 PDGFRB (0.56) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL14949485 0.89 PDGFRB (0.55) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336482 0.88 PDGFRB (0.56) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336424 0.87 PDGFRB (0.54) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336490 0.87 PDGFRB (0.54) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336558 0.86 PDGFRB (0.53) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336421 0.85 PDGFRB (0.61) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL12336500 0.85 PDGFRB (0.53) PDGFRBKITPDGFRACDK11BFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 PDGFRB 497/4885KIT 540/4885PDGFRA 498/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PDGFRB 497/4885KIT 540/4885PDGFRA 498/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 PDGFRB 497/4885KIT 540/4885PDGFRA 498/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.