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Sugi Predict / Compounds / SCHEMBL14949306

SCHEMBL14949306

SCHEMBL14949306

CSc1nc(C)cc(Oc2ccc(Nc3nnc(-c4cccc(C)c4)[nH]3)cc2)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.49
▸ MEN1 O00255 4/20 0.49
▸ HTT P42858 2/20 0.49
▸ LMNA P02545 7/20 0.45
▸ TSHR P16473 2/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ MAPT P10636 5/20 0.41
▸ PDGFRB P09619 1/20 0.38
▸ KIT P10721 1/20 0.38
▸ PDGFRA P16234 1/20 0.38
▸ CDK11B P21127 1/20 0.38
▸ FLT3 P36888 1/20 0.38
▸ CDKL2 Q92772 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ POLB P06746 1/20 0.36
▸ HPGD P15428 3/20 0.35
▸ L3MBTL1 Q9Y468 3/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949579 0.91 PDGFRB (0.48) KMT2AMEN1HTTLMNATSHR
SCHEMBL14949179 0.91 KMT2A (0.47) KMT2AMEN1HTTLMNATSHR
SCHEMBL12336289 0.81 PDGFRB (0.56) KMT2AMEN1HTTLMNATSHR
SCHEMBL14949280 0.80 PDGFRB (0.44) KMT2AMEN1HTTLMNATSHR
SCHEMBL12336721 0.80 PDGFRB (0.47) KMT2AMEN1HTTLMNATSHR
SCHEMBL14949292 0.80 PDGFRB (0.50) KMT2AMEN1HTTLMNATSHR
SCHEMBL12336691 0.78 PDGFRB (0.62) KMT2AMEN1HTTTSHRNPSR1
SCHEMBL14949180 0.78 MAPT (0.53) KMT2AMEN1HTTTSHRNPSR1
SCHEMBL14949336 0.77 PDGFRB (0.41) KMT2AMEN1HTTLMNATSHR
SCHEMBL14949485 0.77 PDGFRB (0.55) KMT2AMEN1HTTLMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 KMT2A 900/4885MEN1 2954/4885HTT 4380/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KMT2A 900/4885MEN1 2954/4885HTT 4380/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KMT2A 900/4885MEN1 2954/4885HTT 4380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.