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Sugi Predict / Compounds / SCHEMBL14949385

SCHEMBL14949385

SCHEMBL14949385

Cc1cccc(Nc2nnc(-c3cccc(Oc4ccnc5cc(OCc6ccccc6)ccc45)c3)[nH]2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 1/20 0.41
▸ PTK6 Q13882 1/20 0.40
▸ KDR P35968 6/20 0.39
▸ MET P08581 4/20 0.39
▸ AXL P30530 2/20 0.39
▸ DYRK1B Q9Y463 2/20 0.39
▸ PDGFRA P16234 1/20 0.38
▸ FGFR2 P21802 2/20 0.38
▸ MAOA P21397 1/20 0.37
▸ HDAC3 O15379 1/20 0.37
▸ HDAC1 Q13547 1/20 0.37
▸ HDAC2 Q92769 1/20 0.37
▸ HDAC8 Q9BY41 1/20 0.37
▸ HDAC6 Q9UBN7 1/20 0.37
▸ DYRK1A Q13627 1/20 0.37
▸ FLT4 P35916 1/20 0.36
▸ TEK Q02763 1/20 0.36
▸ TYRO3 Q06418 1/20 0.36
▸ MERTK Q12866 1/20 0.36
▸ GRM4 Q14833 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949224 0.94 FGFR2 (0.41) SYKPTK6KDRMETAXL
SCHEMBL14949313 0.88 KDR (0.46) KDRMETPDGFRAFGFR2TEK
SCHEMBL12336447 0.88 BRAF (0.44) SYKPTK6KDRMETAXL
SCHEMBL14949367 0.88 KDR (0.42) KDRMETAXLPDGFRAFGFR2
SCHEMBL14949321 0.86 KDR (0.46) KDRMETPDGFRAFGFR2TEK
SCHEMBL14949343 0.85 KDR (0.40) KDRMETPDGFRAFGFR2FLT4
SCHEMBL14949351 0.85 KDR (0.41) KDRMETAXLPDGFRATEK
SCHEMBL14949372 0.83 KDR (0.42) KDRMETAXLPDGFRAFGFR2
SCHEMBL14949208 0.82 KDR (0.46) KDRMETAXLPDGFRAFGFR2
SCHEMBL12336466 0.82 BRAF (0.47) SYKPTK6KDRMETAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 SYK 637/4885PTK6 214/4885KDR 533/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 SYK 637/4885PTK6 214/4885KDR 533/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 SYK 637/4885PTK6 214/4885KDR 533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.