Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12701106 | 1.00 | GPR183 (0.55) | GPR183NPC1RAB9ATDP1TACR1 | |
| SCHEMBL14949462 | 0.92 | GPR183 (0.47) | GPR183NPC1RAB9ATDP1MAPT | |
| SCHEMBL12701131 | 0.92 | GPR183 (0.47) | GPR183NPC1RAB9ATDP1MAPT | |
| SCHEMBL12701185 | 0.91 | GPR183 (0.47) | GPR183NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL14949482 | 0.91 | GPR183 (0.47) | GPR183NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL2897111 | 0.88 | GPR183 (0.51) | GPR183NPC1RAB9ATDP1TACR1 | |
| SCHEMBL2899766 | 0.88 | GPR183 (0.51) | GPR183NPC1RAB9ATDP1TACR1 | |
| SCHEMBL12701088 | 0.88 | GPR183 (0.49) | GPR183NPC1RAB9ATDP1MAPT | |
| SCHEMBL14949442 | 0.88 | GPR183 (0.49) | GPR183NPC1RAB9ATDP1MAPT | |
| SCHEMBL1555217 | 0.88 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491022-B1 | DIAZEPAN DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |
| US-8445674-B2 | Heterocyclyl compounds | Hoffmann-La Roche Inc (US) | 2013-05-21 | — | — | US | disclosed |