Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.52 |
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | BCL6 | P41182 | 1/20 | 0.52 |
| ▸ | NEK4 | P51957 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.52 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.52 |
| ▸ | PMAIP1 | Q13794 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4163378 | 0.85 | MCL1 (0.73) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19178636 | 0.79 | MCL1 (0.59) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL4171023 | 0.72 | MCL1 (0.75) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL4174851 | 0.71 | MCL1 (0.60) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL4161506 | 0.71 | MCL1 (0.81) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL20530954 | 0.70 | MCL1 (0.49) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL4170781 | 0.69 | MCL1 (0.75) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL4154070 | 0.69 | MCL1 (1.00) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL30000183 | 0.69 | MCL1 (1.00) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL4165460 | 0.69 | MCL1 (0.62) | MCL1EEF2KMARK3AXLBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445679-B2 | 7-substituted indole MCL-1 inhibitors | ABBVIE INC. (US) | 2013-05-21 | — | — | US | claimed |