Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 12/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 11/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12917891 | 0.87 | EGLN1 (0.46) | EGLN1EGLN3EGLN2CYSLTR2ALDH1A1 | |
| SCHEMBL963003 | 0.87 | EGLN1 (0.59) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL19531502 | 0.86 | EGLN1 (0.55) | EGLN1EGLN3EGLN2 | |
| SCHEMBL19518391 | 0.86 | EGLN1 (0.58) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL13017097 | 0.85 | EGLN1 (0.66) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL17629656 | 0.83 | EGLN1 (0.64) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL960004 | 0.80 | EGLN1 (0.64) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL14685855 | 0.80 | EGLN1 (0.44) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL962259 | 0.79 | EGLN1 (0.59) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL12917909 | 0.79 | EGLN1 (0.59) | EGLN1EGLN3EGLN2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257169-B1 | TETRAHYDROTHIENO PYRIDINES | MERCK SHARP & DOHME (US) | 2013-06-05 | — | — | EP | disclosed |
| US-8445680-B2 | Tetrahydrothieno pyridines | MERCK SHARP & DOHME CORP. (US) | 2013-05-21 | — | — | US | disclosed |