Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.52 |
| ▸ | EGLN2 | Q96KS0 | 14/20 | 0.52 |
| ▸ | EGLN3 | Q9H6Z9 | 14/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12917952 | 0.95 | EGLN1 (0.51) | EGLN1EGLN2EGLN3CYSLTR2 | |
| Trifluoroacetic Acid SCHEMBL959410 | 0.93 | EGLN1 (0.52) | EGLN1EGLN2EGLN3CYSLTR2 | |
| Trifluoroacetic Acid SCHEMBL961531 | 0.91 | EGLN1 (0.51) | EGLN1EGLN2EGLN3CYSLTR2 | |
| Trifluoroacetic Acid SCHEMBL959711 | 0.91 | EGLN1 (0.54) | EGLN1EGLN2EGLN3CYSLTR2 | |
| Trifluoroacetic Acid SCHEMBL960595 | 0.91 | EGLN1 (0.52) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL12917939 | 0.89 | EGLN1 (0.56) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL12917959 | 0.88 | EGLN1 (0.51) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL959242 | 0.88 | EGLN1 (0.53) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL12917942 | 0.86 | EGLN1 (0.49) | EGLN1EGLN2EGLN3CYSLTR2 | |
| Trifluoroacetic Acid SCHEMBL961435 | 0.86 | EGLN1 (0.55) | EGLN1EGLN2EGLN3CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257169-B1 | TETRAHYDROTHIENO PYRIDINES | MERCK SHARP & DOHME (US) | 2013-06-05 | — | — | EP | claimed |
| US-8445680-B2 | Tetrahydrothieno pyridines | MERCK SHARP & DOHME CORP. (US) | 2013-05-21 | — | — | US | claimed |
| EP-2257169-B1 | TETRAHYDROTHIENO PYRIDINES | MERCK SHARP & DOHME (US) | 2013-06-05 | — | — | EP | disclosed |