Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10034147 | 0.83 | CFTR (0.48) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL10066236 | 0.83 | CFTR (0.48) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL19027867 | 0.81 | CFTR (0.55) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL23005915 | 0.78 | CFTR (0.54) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL23800934 | 0.78 | CFTR (0.54) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL29512297 | 0.75 | CFTR (0.55) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL19412364 | 0.75 | CFTR (0.55) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL19412365 | 0.74 | CFTR (0.59) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL29592296 | 0.74 | CFTR (0.59) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL17793953 | 0.72 | CFTR (0.41) | CFTRHTR2APDE4DSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013070961-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-16 | — | — | WO | disclosed |