Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14953458 | 0.88 | PIK3CA (0.51) | PIK3CACREBBPMTOR | |
| SCHEMBL3790868 | 0.88 | PIK3CA (0.63) | PIK3CACREBBPMTOR | |
| SCHEMBL14953478 | 0.88 | PIK3CA (0.46) | PIK3CACREBBP | |
| SCHEMBL12979899 | 0.85 | PIK3CA (0.50) | PIK3CACREBBPMTOR | |
| SCHEMBL14953448 | 0.84 | PIK3CA (0.49) | PIK3CACREBBP | |
| SCHEMBL7878884 | 0.84 | PIK3CA (0.48) | PIK3CACREBBP | |
| SCHEMBL14953323 | 0.82 | PIK3CA (0.48) | PIK3CACREBBP | |
| SCHEMBL14953384 | 0.81 | PIK3CA (0.48) | PIK3CACREBBP | |
| SCHEMBL14953398 | 0.81 | PIK3CA (0.48) | PIK3CACREBBP | |
| SCHEMBL14953408 | 0.81 | PIK3CA (0.48) | PIK3CACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435426-B1 | BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS INC (US) | 2013-05-22 | — | — | EP | claimed |