SCHEMBL14959764

Nc1nc(/C(=N\OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CO)CC[C@H]23)ns1

nearest known ligand 0.35

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	KCNH2	Q12809	1/20	0.35

▸	NR1I2	O75469	2/20	0.32

▸	ESR1	P03372	1/20	0.32

▸	PGR	P06401	1/20	0.32

▸	PPARG	P37231	1/20	0.32

▸	ABCB11	O95342	1/20	0.32

▸	PTGS1	P23219	1/20	0.32

▸	PDE4D	Q08499	1/20	0.32

▸	HSD17B10	Q99714	1/20	0.32

▸	TDP1	Q9NUW8	1/20	0.32

▸	KMT2A	Q03164	1/20	0.31

▸	ABCC4	O15439	1/20	0.31

▸	PDE4A	P27815	1/20	0.31

▸	HTR2C	P28335	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12306317	1.00	KCNH2 (0.35)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL12334100	1.00	KCNH2 (0.35)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL12306318	0.90	KMT2A (0.37)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL14959766	0.90	KMT2A (0.37)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL12334095	0.90	KMT2A (0.37)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL14959767	0.90	KCNH2 (0.35)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL12306316	0.90	KCNH2 (0.35)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL12334104	0.90	KCNH2 (0.35)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL2595316	0.88	KCNH2 (0.44)	KCNH2NR1I2ESR1PGRPPARG
SCHEMBL14773850	0.88	KCNH2 (0.44)	KCNH2NR1I2ESR1PGRPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8445476-B2	Carbacephem β-lactam antibiotics	ACHAOGEN, INC. (US)	2013-05-21	—	—	US	disclosed