Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878456 | 0.93 | PIK3CA (0.58) | PIK3CACREBBP | |
| SCHEMBL7865168 | 0.92 | PIK3CA (0.59) | PIK3CACREBBP | |
| SCHEMBL7881738 | 0.91 | PIK3CA (0.59) | PIK3CACREBBP | |
| SCHEMBL3798626 | 0.91 | PIK3CA (0.67) | PIK3CACREBBP | |
| SCHEMBL7860453 | 0.90 | PIK3CA (0.60) | PIK3CACREBBP | |
| SCHEMBL3793151 | 0.90 | PIK3CA (0.60) | PIK3CACREBBP | |
| SCHEMBL3789162 | 0.88 | PIK3CA (0.64) | PIK3CACREBBP | |
| SCHEMBL3789421 | 0.87 | PIK3CA (0.60) | PIK3CACREBBP | |
| SCHEMBL3792896 | 0.85 | PIK3CA (0.59) | PIK3CACREBBP | |
| SCHEMBL3790868 | 0.83 | PIK3CA (0.63) | PIK3CACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435426-B1 | BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS INC (US) | 2013-05-22 | — | — | EP | disclosed |