Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496317 | 1.00 | GRM2 (1.00) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL30120569 | 1.00 | GRM2 (1.00) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1496376 | 1.00 | GRM2 (1.00) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL10324288 | 0.94 | GRM2 (0.89) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL6884741 | 0.94 | GRM2 (0.89) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1495851 | 0.94 | GRM2 (0.88) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1495854 | 0.94 | GRM2 (0.88) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1496035 | 0.90 | GRM2 (0.82) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1496031 | 0.90 | GRM2 (0.82) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1496299 | 0.86 | GRM2 (0.75) | GRM2KDM4EMAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477994-A1 | SUBSTITUTED DIHYDRO BENZOCYCLOALKYLOXYMETHYL OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011034830-A1 | SUBSTITUTED DIHYDRO BENZOCYCLOALKYLOXYMETHYL OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | WO | disclosed |