Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FER | P16591 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12237301 | 0.82 | PDK2 (0.53) | PDK2PDK4MGAT2BRD4CREBBP | |
| SCHEMBL29789747 | 0.82 | PDK2 (0.52) | PDK2PDK4MGAT2BRD4CREBBP | |
| SCHEMBL757520 | 0.82 | PDK2 (0.52) | PDK2PDK4MGAT2BRD4CREBBP | |
| SCHEMBL18177174 | 0.80 | PDK2 (0.50) | PDK2PDK4MGAT2BRD4CREBBP | |
| SCHEMBL14328387 | 0.76 | PDK2 (0.46) | PDK2PDK4MGAT2BRD4CREBBP | |
| SCHEMBL3516954 | 0.74 | BACE1 (0.50) | PDK2PDK4BACE1POLBMEN1 | |
| SCHEMBL17586345 | 0.74 | PDK2 (0.41) | PDK2PDK4MGAT2BRD4CREBBP | |
| SCHEMBL9591821 | 0.71 | PDK2 (0.71) | PDK2PDK4BRD4CREBBPEP300 | |
| SCHEMBL29622026 | 0.68 | BACE1 (0.68) | PDK2PDK4BACE1POLBMEN1 | |
| SCHEMBL17350152 | 0.68 | PDE7A (0.42) | PDK2PDK4BACE1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130126443-A1 | CARBON SUPPORTED TETRAAMIDO MACROCYCLIC LIGAND CATALYTIC ACTIVATORS AND METHODS FOR MAKING THE SAME | CARNEGIE MELLON UNIVERSITY (US) | 2013-05-23 | — | — | US | disclosed |