Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 7/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.40 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9273037 | 0.81 | TSHR (0.46) | POLBDAOALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL13015570 | 0.80 | DAO (0.46) | PARP1DAOPBRM1ALDH1A1NAPRT | |
| SCHEMBL9995469 | 0.78 | DAO (0.60) | POLBDAOPGRCYP3A4CYP2B6 | |
| SCHEMBL798322 | 0.76 | POLB (0.51) | POLBPARP1DAOPGRPBRM1 | |
| SCHEMBL20079383 | 0.73 | POLB (0.51) | POLBDAOPGRCYP3A4CYP2B6 | |
| SCHEMBL13387320 | 0.72 | DAO (0.40) | PARP1DAOPBRM1B3GNT2ALDH1A1 | |
| SCHEMBL2960319 | 0.71 | KDM4E (0.42) | POLBPARP1DAOPBRM1ALDH1A1 | |
| SCHEMBL9272114 | 0.70 | POLB (0.48) | POLBALDH1A1L3MBTL1 | |
| SCHEMBL828232 | 0.68 | POLB (1.00) | POLBDAOPGRALDH1A1L3MBTL1 | |
| SCHEMBL2969357 | 0.68 | POLB (0.49) | POLBDAOPGRB3GNT2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483290-A1 | CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011038293-A1 | CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| EP-0591026-A1 | Piperidine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-04-06 | — | — | EP | disclosed |