SCHEMBL14964270

SCHEMBL14964270

O=S(=O)(CCCN1CCOCC1)NCc1nonc1C(=Nc1ccc(F)c(Cl)c1)NO

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 19/20 0.51
TDO2 P48775 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4972216 0.88 IDO1 (0.40) IDO1TDO2
SCHEMBL5631332 0.86 IDO1 (0.54) IDO1TDO2
SCHEMBL4981740 0.86 IDO1 (0.57) IDO1TDO2
SCHEMBL14442650 0.85 EPHX2 (0.41)
SCHEMBL5631275 0.84 IDO1 (0.56) IDO1TDO2
SCHEMBL5631485 0.84 IDO1 (0.59) IDO1TDO2
SCHEMBL16588230 0.84 EGFR (0.40)
SCHEMBL5632611 0.83 IDO1 (0.58) IDO1TDO2
SCHEMBL4986046 0.82 IDO1 (0.60) IDO1TDO2
SCHEMBL5630958 0.82 IDO1 (0.61) IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8450351-B2 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2013-05-28 US claimed