Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14443034 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL4981954 | 0.96 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL4981944 | 0.96 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14462385 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4981946 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4981948 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14443033 | 0.83 | MAOB (0.40) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14443032 | 0.83 | NPC1 (0.41) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14964168 | 0.83 | MAOB (0.40) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14964263 | 0.83 | NPC1 (0.41) | SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971583-B1 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORP (US) | 2015-03-25 | — | — | EP | claimed |
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |