Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964732 | 0.85 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14964930 | 0.83 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14965452 | 0.83 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14965151 | 0.83 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14965940 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14965132 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14965258 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL16293966 | 0.73 | KMT2A (0.70) | SMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL14964974 | 0.71 | POLB (0.58) | POLBHTTKMT2A | |
| SCHEMBL14965285 | 0.71 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |