Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965022 | 1.00 | MEN1 (0.46) | MEN1KMT2AATMSMN1; SMN2MAPT | |
| SCHEMBL14965136 | 0.93 | KMT2A (0.49) | KMT2A | |
| SCHEMBL14965284 | 0.93 | KMT2A (0.49) | KMT2A | |
| SCHEMBL14965021 | 0.77 | KMT2A (0.49) | MEN1KMT2AATMMAPTADRB3 | |
| SCHEMBL14965265 | 0.77 | KMT2A (0.49) | MEN1KMT2AATMMAPTADRB3 | |
| SCHEMBL14965023 | 0.77 | KMT2A (0.49) | MEN1KMT2AATMMAPTADRB3 | |
| SCHEMBL14965291 | 0.76 | MEN1 (0.57) | MEN1KMT2AATMSMN1; SMN2MAPT | |
| SCHEMBL14964844 | 0.76 | MEN1 (0.57) | MEN1KMT2AATMSMN1; SMN2MAPT | |
| SCHEMBL14965250 | 0.72 | KMT2A (0.44) | KMT2AADRB3 | |
| SCHEMBL14965389 | 0.72 | KMT2A (0.50) | MEN1KMT2AATMSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |