Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14972131 | 0.91 | POLB (0.43) | KLKB1MEN1ALDH1A1KMT2APOLB | |
| SCHEMBL14967419 | 0.86 | SMN1; SMN2 (0.45) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14967406 | 0.86 | SMN1; SMN2 (0.45) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14966658 | 0.86 | SMN1; SMN2 (0.45) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14966826 | 0.84 | SMN1; SMN2 (0.41) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14967045 | 0.84 | SMN1; SMN2 (0.41) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14966630 | 0.84 | KLKB1 (0.41) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14972008 | 0.82 | EZH2 (0.53) | — | |
| SCHEMBL14966641 | 0.82 | SMN1; SMN2 (0.40) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E | |
| SCHEMBL14967364 | 0.82 | KDM4E (0.41) | KLKB1SMN1; SMN2OPRM1OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |