Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TPH1 | P17752 | 4/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870963 | 1.00 | KLKB1 (0.45) | KLKB1ITGA4KMT2ATPH1AAK1 | |
| SCHEMBL5607803 | 0.83 | MAPT (0.60) | KLKB1ITGA4KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5607808 | 0.83 | MAPT (0.60) | KLKB1ITGA4KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL27747389 | 0.81 | ITGB1 (0.46) | KLKB1ITGA4TPH1MAPTSMN1; SMN2 | |
| SCHEMBL5213839 | 0.75 | PPARG (0.63) | ITGA4TPH1ITGB1ALPIPKM | |
| SCHEMBL7227938 | 0.75 | PPARG (0.63) | ITGA4TPH1ITGB1ALPIPKM | |
| SCHEMBL31398354 | 0.75 | PPARG (0.63) | ITGA4TPH1ITGB1ALPIPKM | |
| SCHEMBL5607009 | 0.74 | CA1 (0.58) | KLKB1ITGA4KMT2ASMN1; SMN2ITGB1 | |
| SCHEMBL5082946 | 0.74 | CA1 (0.58) | KLKB1ITGA4KMT2ASMN1; SMN2ITGB1 | |
| SCHEMBL5607007 | 0.73 | FFAR1 (0.65) | ITGA4KMT2AMAPTSMN1; SMN2ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074889-A1 | METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-05-23 | — | — | WO | disclosed |