Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 19/20 | 0.77 |
| ▸ | BCL2L1 | Q07817 | 18/20 | 0.77 |
| ▸ | BCL2L2 | Q92843 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497066 | 0.95 | BCL2 (0.70) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497184 | 0.95 | BCL2 (0.69) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497099 | 0.95 | BCL2 (0.69) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497116 | 0.93 | BCL2 (0.67) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497172 | 0.93 | BCL2 (0.77) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497196 | 0.93 | BCL2 (0.66) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497188 | 0.92 | BCL2 (0.77) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951716 | 0.91 | BCL2 (0.72) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9952251 | 0.91 | BCL2 (0.84) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL10166414 | 0.91 | BCL2 (0.84) | BCL2BCL2L1BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475661-A1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029842-A1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2011-03-17 | — | — | WO | disclosed |