Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497323 | 0.82 | PIK3CA (0.69) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1497325 | 0.82 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1497327 | 0.81 | PIK3CA (0.65) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1497329 | 0.81 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL30366491 | 0.80 | PIK3CA (0.73) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1497360 | 0.79 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2394522 | 0.75 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4438673 | 0.75 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL26079614 | 0.73 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1497580 | 0.72 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475375-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011031896-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |