Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dibenzepin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.94 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.94 |
| ▸ | DRD2 | P14416 | 4/20 | 0.94 |
| ▸ | HTR6 | P50406 | 4/20 | 0.94 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.94 |
| ▸ | HTR1A | P08908 | 3/20 | 0.94 |
| ▸ | HTR2A | P28223 | 3/20 | 0.94 |
| ▸ | HTR7 | P34969 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.94 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.94 |
| ▸ | MAPT | P10636 | 1/20 | 0.94 |
| ▸ | DRD1 | P21728 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.94 |
| ▸ | DRD3 | P35462 | 1/20 | 0.94 |
| ▸ | HEXA | P06865 | 1/20 | 0.52 |
| ▸ | HEXB | P07686 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibenzepin SCHEMBL29354805 | 0.97 | HRH1 (1.00) | HRH1DRD2HTR6SLC6A4HTR1A | |
| Dibenzepin SCHEMBL49286 | 0.97 | HRH1 (1.00) | HRH1DRD2HTR6SLC6A4HTR1A | |
| Dibenzepin SCHEMBL29375228 | 0.95 | HRH1 (0.97) | HRH1DRD2HTR6SLC6A4HTR1A | |
| Dibenzepin SCHEMBL668219 | 0.95 | HRH1 (0.97) | HRH1DRD2HTR6SLC6A4HTR1A | |
| Dimetacrine SCHEMBL28221926 | 0.82 | HRH1 (0.71) | HRH1DRD2HTR6SLC6A4HTR1A | |
| SCHEMBL11746213 | 0.82 | HRH1 (0.72) | HRH1DRD2HTR6SLC6A4HTR1A | |
| SCHEMBL29492639 | 0.80 | HRH1 (0.69) | HRH1DRD2HTR6SLC6A4HTR1A | |
| Dibenzepin SCHEMBL28086113 | 0.80 | HRH1 (0.68) | HRH1DRD2HTR6SLC6A4HTR1A | |
| SCHEMBL30839875 | 0.79 | HEXA (0.72) | HRH1DRD2HTR6SLC6A4HTR1A | |
| SCHEMBL13590076 | 0.79 | HEXA (0.72) | HRH1DRD2HTR6SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| US-20130137099-A1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS | KYOTO UNIVERSITY (JP) | 2013-05-30 | — | — | US | disclosed |