Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 11/20 | 0.57 |
| ▸ | SYK | P43405 | 4/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914264 | 0.90 | JAK3 (0.56) | STAT6SYKJAK1JAK3MAP4K3 | |
| SCHEMBL914805 | 0.88 | JAK3 (0.57) | STAT6SYKJAK1JAK3JAK2 | |
| SCHEMBL913836 | 0.84 | JAK1 (0.52) | SYKJAK1JAK3JAK2MAP4K3 | |
| SCHEMBL20759912 | 0.78 | STAT6 (0.59) | STAT6SYK | |
| SCHEMBL2386600 | 0.78 | STAT6 (0.81) | STAT6SYKJAK1JAK3JAK2 | |
| SCHEMBL10229041 | 0.77 | STAT6 (0.65) | STAT6SYK | |
| SCHEMBL914262 | 0.77 | JAK1 (0.48) | SYKJAK1JAK3JAK2MAP4K3 | |
| SCHEMBL20760050 | 0.77 | STAT6 (0.58) | STAT6SYKJAK1JAK3JAK2 | |
| SCHEMBL30122076 | 0.77 | STAT6 (0.58) | STAT6SYKJAK1JAK3JAK2 | |
| SCHEMBL913623 | 0.75 | STAT6 (0.64) | STAT6SYKJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130137673-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | claimed |
| US-8853230-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130137673-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137673-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | STAT6 16/4885SYK 72/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.