Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | MYT1 | Q01538 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30980046 | 0.84 | NAMPT (0.49) | PDPK1NAMPTDPP4DPP8PARP1 | |
| SCHEMBL1497458 | 0.77 | HTT (0.44) | PDPK1 | |
| SCHEMBL22127224 | 0.72 | SCD (0.43) | NAMPTCDK1MYT1SPR | |
| SCHEMBL22977583 | 0.72 | DPP4 (0.49) | PDPK1NAMPTDPP4DPP8PARP1 | |
| SCHEMBL16219018 | 0.69 | DPP4 (0.49) | PDPK1NAMPTDPP4DPP8PARP1 | |
| SCHEMBL25937534 | 0.69 | DPP4 (0.55) | PDPK1NAMPTDPP4DPP8PARP1 | |
| SCHEMBL12208897 | 0.69 | NAMPT (0.45) | PDPK1NAMPTDPP4DPP8PARP1 | |
| SCHEMBL348289 | 0.69 | — | — | |
| SCHEMBL25428982 | 0.69 | DPP4 (0.39) | PDPK1NAMPTDPP4DPP8PARP1 | |
| SCHEMBL25428980 | 0.69 | DPP4 (0.39) | PDPK1NAMPTDPP4DPP8PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475661-A1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029842-A1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2011-03-17 | — | — | WO | disclosed |