Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.60 |
| ▸ | GRM5 | P41594 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18342015 | 0.84 | FFAR1 (0.56) | FFAR1GRM5NPC1MAPTKMT2A | |
| SCHEMBL18741024 | 0.79 | FFAR1 (0.54) | FFAR1GRM5NPC1SMN1; SMN2KDM4E | |
| SCHEMBL30751147 | 0.79 | FFAR1 (0.54) | FFAR1GRM5NPC1SMN1; SMN2KDM4E | |
| SCHEMBL18952028 | 0.77 | MAPT (0.57) | FFAR1GRM5NPC1SMN1; SMN2KDM4E | |
| SCHEMBL4333501 | 0.77 | NPC1 (0.47) | FFAR1GRM5NPC1SMN1; SMN2KDM4E | |
| SCHEMBL21645908 | 0.77 | NPC1 (0.43) | FFAR1GRM5NPC1SMN1; SMN2KDM4E | |
| SCHEMBL18188087 | 0.76 | GRM5 (0.53) | FFAR1GRM5NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14976485 | 0.74 | APP (0.48) | FFAR1GRM5MAPTAPPGRM4 | |
| SCHEMBL1541679 | 0.74 | KMT2A (0.46) | FFAR1GRM5NPC1SMN1; SMN2MEN1 | |
| SCHEMBL3251978 | 0.74 | GRM5 (0.55) | FFAR1GRM5NPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078254-A1 | BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-05-30 | — | — | WO | disclosed |