Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976339 | 0.90 | RPS6KB1 (0.46) | SYKTNIKAURKARPS6KB1EGFR | |
| SCHEMBL14956331 | 0.90 | SYK (0.47) | SYKTNIKAURKARPS6KB1EGFR | |
| SCHEMBL14956333 | 0.90 | SYK (0.47) | SYKTNIKAURKARPS6KB1EGFR | |
| SCHEMBL14975714 | 0.80 | JAK3 (0.46) | SYKTNIKRPS6KB1JAK2JAK3 | |
| SCHEMBL14975708 | 0.80 | SYK (0.40) | SYKRPS6KB1EGFRJAK2JAK3 | |
| SCHEMBL14955870 | 0.80 | AURKA (0.46) | SYKTNIKAURKARPS6KB1EGFR | |
| SCHEMBL14955869 | 0.80 | AURKA (0.46) | SYKTNIKAURKARPS6KB1EGFR | |
| SCHEMBL14975942 | 0.77 | SYK (0.50) | SYKRPS6KB1EGFRJAK2JAK3 | |
| SCHEMBL14977027 | 0.75 | BTK (0.46) | SYKRPS6KB1JAK2JAK3KDM4E | |
| SCHEMBL14975905 | 0.75 | SYK (0.52) | SYKRPS6KB1EGFRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782579-A1 | PYRAZINE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |