Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976276 | 1.00 | SYK (0.58) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL1848277 | 0.87 | SYK (0.64) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL1849946 | 0.87 | SYK (0.63) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL1849939 | 0.87 | SYK (0.63) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL1848307 | 0.83 | SYK (0.60) | SYK | |
| SCHEMBL1848308 | 0.83 | SYK (0.60) | SYK | |
| SCHEMBL1847945 | 0.80 | SYK (0.62) | SYK | |
| SCHEMBL1847941 | 0.80 | SYK (0.62) | SYK | |
| SCHEMBL14975839 | 0.77 | SYK (0.84) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL14981540 | 0.77 | SYK (0.77) | SYKAURKBKCNH2ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782580-A1 | SELECTIVE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |