Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975825 | 0.89 | SYK (0.35) | SYKBTKCDC7PLK4CHEK1 | |
| SCHEMBL16205091 | 0.84 | BTK (0.33) | BTKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14955818 | 0.82 | SYK (0.36) | SYKBTKCDC7PLK4CHEK1 | |
| SCHEMBL14955821 | 0.82 | SYK (0.36) | SYKBTKCDC7PLK4CHEK1 | |
| SCHEMBL16205136 | 0.73 | BTK (0.33) | BTKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL16205158 | 0.73 | BTK (0.33) | BTKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14975791 | 0.73 | — | — | |
| SCHEMBL20613139 | 0.72 | SYK (0.37) | SYKBTKCDC7PLK4CHEK1 | |
| SCHEMBL14955878 | 0.70 | SYK (0.36) | SYKBTKCDC7PLK4CHEK1 | |
| SCHEMBL14975827 | 0.70 | BTK (0.34) | SYKBTKCDC7PLK4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782579-A1 | PYRAZINE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |