Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325170 | 0.84 | HRH3 (0.44) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL13506436 | 0.82 | HRH3 (0.46) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL13387471 | 0.82 | HRH3 (0.46) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL8303908 | 0.80 | HRH3 (0.43) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL7451255 | 0.80 | HRH3 (0.43) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL4683301 | 0.79 | HRH3 (0.42) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL23160898 | 0.77 | HRH3 (0.40) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL38661176 | 0.77 | EPHX1 (0.47) | EPHX1SMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL3655319 | 0.77 | HRH3 (0.41) | HRH3TSHREPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL9822641 | 0.76 | HRH3 (0.39) | HRH3TSHREPHX1EPHX2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782903-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013076063-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-30 | — | — | WO | disclosed |