Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.66 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.66 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.51 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975963 | 0.85 | PARP1 (0.69) | PARP1PARP2SERPINE1PARP3TDO2 | |
| SCHEMBL14976135 | 0.82 | SERPINE1 (0.73) | PARP1PARP2SERPINE1PARP3 | |
| SCHEMBL14977380 | 0.80 | PARP1 (1.00) | PARP1PARP2PARP3 | |
| SCHEMBL30419055 | 0.80 | PARP1 (1.00) | PARP1PARP2PARP3 | |
| Hydrochloric Acid SCHEMBL14976144 | 0.79 | PARP1 (0.98) | PARP1PARP2PARP3 | |
| SCHEMBL14976004 | 0.77 | SERPINE1 (0.66) | PARP1PARP2SERPINE1PARP3 | |
| SCHEMBL853270 | 0.76 | SERPINE1 (0.69) | PARP1PARP2SERPINE1PARP3 | |
| SCHEMBL14977334 | 0.76 | PARP1 (0.65) | PARP1PARP2SERPINE1PARP3 | |
| SCHEMBL14976380 | 0.74 | PARP1 (0.62) | PARP1PARP2SERPINE1PARP3 | |
| SCHEMBL16227079 | 0.74 | PARP1 (0.68) | PARP1PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788328-B1 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2018-01-31 | — | — | EP | disclosed |
| US-9422243-B2 | 3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. a corporation (IT) | 2016-08-23 | — | — | US | disclosed |
| US-20140336192-A1 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. a corporation | 2014-11-13 | — | — | US | disclosed |
| EP-2788328-A1 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013076090-A1 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336192-A1 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | PARP1 1/4885PARP2 2/4885SERPINE1 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.