Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.68 |
| ▸ | MTOR | P42345 | 2/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.59 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.59 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | STK16 | O75716 | 1/20 | 0.59 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1864435 | 0.90 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1857591 | 0.90 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1861618 | 0.87 | PIK3CA (0.69) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1864562 | 0.87 | PIK3CA (0.71) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1860731 | 0.87 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1865477 | 0.87 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1865746 | 0.86 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1862050 | 0.86 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1497490 | 0.86 | PIK3CA (0.63) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1864464 | 0.86 | PIK3CA (0.69) | PIK3CAMTORPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475375-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011031896-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |