Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Etoposide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 4/20 | 0.81 |
| ▸ | TOP2B known ✓ | Q02880 | 4/20 | 0.81 |
| ▸ | GAA | P10253 | 6/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.81 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.81 |
| ▸ | ATM | Q13315 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etoposide SCHEMBL3497224 | 0.92 | CYP3A4 (0.92) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL16568315 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL6361654 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL12308309 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL24482748 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL23064754 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL14401267 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL20598257 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL22594950 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B | |
| Etoposide SCHEMBL13439889 | 0.90 | CYP3A4 (1.00) | GAACYP3A4SMN1; SMN2TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130143824-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| US-20120058953-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20110039324-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2011-02-17 | — | — | US | disclosed |
| US-20090148921-A1 | Compositions and methods for enhancing apoptosis | GENENTECH, INC. (US) | 2009-06-11 | — | — | US | disclosed |
| EP-1590666-B1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH INC (US) | 2008-07-09 | — | — | EP | disclosed |
| US-20060246471-A1 | Compositions and methods for screening pro-apoptotic compounds | GENENTECH, INC. (US) | 2006-11-02 | — | — | US | disclosed |
| EP-1687431-A2 | COMPOSITIONS AND METHODS FOR SCREENING PRO-APOPTOTIC COMPOUNDS | Genentech, Inc. (US) | 2006-08-09 | — | — | EP | disclosed |
| EP-1590666-A4 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH INC (US) | 2006-07-26 | — | — | EP | disclosed |
| US-7067274-B2 | Compositions and methods for the screening pro-apoptotic compounds | GENENTECH, INC. (US) | 2006-06-27 | — | — | US | disclosed |
| EP-1590666-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | Genentech, Inc. (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20050214802-A1 | Compositions and methods for the screening pro-apoptotic compounds | GENENTECH, INC. (US) | 2005-09-29 | — | — | US | disclosed |
| WO-2005049853-A2 | COMPOSITIONS AND METHODS FOR SCREENING PRO-APOPTOTIC COMPOUNDS | GENENTECH, INC. (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20040171554-A1 | Compositions and methods for enhancing apoptosis | GENENTECH, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2004072641-A1 | COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS | GENENTECH, INC. (US) | 2004-08-26 | — | — | WO | disclosed |