Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 8/20 | 0.38 |
| ▸ | LTA4H | P09960 | 4/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14979454 | 0.80 | HDAC1 (0.42) | CHEK1MEN1KMT2AAURKARPS6KB1 | |
| SCHEMBL14979304 | 0.72 | KDM4E (0.46) | CHEK1MEN1KMT2A | |
| SCHEMBL10496394 | 0.69 | TAAR1 (0.57) | EPHX2 | |
| SCHEMBL14813680 | 0.69 | TAAR1 (0.57) | EPHX2 | |
| SCHEMBL4025807 | 0.68 | FLT4 (1.00) | FESFGFR1FLT4KDRCHEK1 | |
| SCHEMBL13576621 | 0.67 | EED (0.59) | KMT2ALTA4H | |
| SCHEMBL3890476 | 0.67 | EED (0.59) | KMT2ALTA4H | |
| SCHEMBL14979456 | 0.67 | HDAC1 (0.41) | — | |
| SCHEMBL21460332 | 0.66 | MAPT (0.43) | CHEK1LTA4H | |
| SCHEMBL4027877 | 0.65 | FES (0.77) | FESFGFR1FLT4KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450348-B2 | Such as 3-[6-(4-Chloro-phenoxy)-hexylamino]-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione; cancer, tumors; reduced side effects | FORMA TM, LLC (US) | 2013-05-28 | — | — | US | disclosed |