Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 15/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972653 | 0.86 | AOC3 (0.81) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL971452 | 0.84 | AOC3 (0.61) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL972875 | 0.83 | AOC3 (0.71) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL972158 | 0.83 | AOC3 (0.60) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4866948 | 0.81 | AOC3 (0.68) | AOC3NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL12947793 | 0.80 | AOC3 (0.66) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16242465 | 0.80 | AOC3 (0.66) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL973735 | 0.80 | AOC3 (0.69) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL973247 | 0.80 | AOC3 (0.69) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3407382 | 0.80 | AOC3 (0.69) | AOC3NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450527-B2 | Amine derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC. (US) | 2013-05-28 | — | — | US | disclosed |