⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16326346 | 1.00 | — | — | |
| SCHEMBL14433371 | 1.00 | — | — | |
| SCHEMBL27980200 | 0.76 | — | — | |
| SCHEMBL14980241 | 0.74 | — | — | |
| SCHEMBL810657 | 0.74 | — | — | |
| SCHEMBL518623 | 0.74 | DPP4 (0.33) | — | |
| SCHEMBL14980225 | 0.74 | — | — | |
| SCHEMBL10177500 | 0.72 | — | — | |
| SCHEMBL14980243 | 0.72 | — | — | |
| SCHEMBL13079166 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450522-B2 | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders | AMGEN INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20100298367-A1 | Conformationally Constrained Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders | AMGEN INC. | 2010-11-25 | — | — | US | disclosed |