Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.82 |
| ▸ | FABP1 | P07148 | 1/20 | 0.73 |
| ▸ | FABP6 | P51161 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GPR39 | O43194 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29580040 | 1.00 | KDM4E (1.00) | KDM4ECXCR4FABP1FABP6NPC1 | |
| Alcohol SCHEMBL14813466 | 0.92 | KDM4E (0.85) | KDM4ECXCR4FABP1FABP6NPC1 | |
| SCHEMBL28469695 | 0.91 | KDM4E (0.82) | KDM4ECXCR4FABP1FABP6NPC1 | |
| SCHEMBL29351380 | 0.91 | CXCR4 (1.00) | KDM4ECXCR4FABP1FABP6NPC1 | |
| SCHEMBL589266 | 0.91 | CXCR4 (1.00) | KDM4ECXCR4FABP1FABP6NPC1 | |
| SCHEMBL10055030 | 0.85 | CXCR4 (0.89) | KDM4ECXCR4FABP1FABP6NPC1 | |
| SCHEMBL29664808 | 0.85 | FABP1 (1.00) | KDM4ECXCR4FABP1FABP6NPC1 | |
| SCHEMBL2230559 | 0.85 | FABP1 (1.00) | KDM4ECXCR4FABP1FABP6NPC1 | |
| Hydrochloric Acid SCHEMBL4696844 | 0.83 | FABP1 (0.96) | KDM4ECXCR4FABP1FABP6NPC1 | |
| Fluoride SCHEMBL28270594 | 0.83 | FABP1 (0.96) | KDM4ECXCR4FABP1FABP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336750-B | Dithioacetal-containing pyridopyrimidone derivative and preparation and application thereof | 贵州大学 | 2022-06-07 | — | — | CN | disclosed |
| CN-113651811-B | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2022-06-07 | — | — | CN | disclosed |
| CN-113651811-A | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2021-11-16 | — | — | CN | disclosed |
| CN-113336750-A | Dithioacetal-containing pyridopyrimidone derivative and preparation and application thereof | 贵州大学 | 2021-09-03 | — | — | CN | disclosed |
| WO-2018033019-A1 | OXAZOLOPYRIDINE QUATERNARY AMMONIUM SALT COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-02-22 | — | — | WO | disclosed |
| US-9394253-B2 | Kinase protein binding inhibitors | HEALTH RESEARCH, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394253-B2 | Kinase protein binding inhibitors | HEALTH RESEARCH, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150051245-A1 | KINASE PROTEIN BINDING INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-19 | — | — | US | disclosed |
| US-20150051245-A1 | KINASE PROTEIN BINDING INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-19 | — | — | US | disclosed |
| WO-2013074517-A1 | KINASE PROTEIN BINDING INHIBITORS | ROSWELL PARK CANCER INSTITUTE (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051245-A1 | KINASE PROTEIN BINDING INHIBITORS | PACSIN2, PRKCH, CKS1B | KDM4E 1311/4885CXCR4 1754/4885FABP1 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.