Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126874 | 0.91 | POLB (0.46) | POLBROCK2PDE3BPDE3ANAMPT | |
| SCHEMBL16506011 | 0.91 | POLB (0.46) | POLBROCK2PDE3BPDE3ANAMPT | |
| SCHEMBL16506010 | 0.91 | POLB (0.46) | POLBROCK2PDE3BPDE3ANAMPT | |
| SCHEMBL2695221 | 0.77 | PIM2 (0.43) | PIM1PIM3PIM2 | |
| SCHEMBL2836092 | 0.77 | PIM1 (0.51) | POLBROCK2NPC1RAB9APIM1 | |
| SCHEMBL2836090 | 0.77 | PIM1 (0.51) | POLBROCK2NPC1RAB9APIM1 | |
| SCHEMBL4127327 | 0.77 | PIM1 (0.51) | POLBROCK2NPC1RAB9APIM1 | |
| SCHEMBL16587844 | 0.76 | POLB (0.49) | POLBROCK2PDE3BPDE3ANAMPT | |
| SCHEMBL4121405 | 0.76 | POLB (0.44) | POLBROCK2NAMPTNPC1RAB9A | |
| SCHEMBL2837177 | 0.76 | POLB (0.44) | POLBROCK2NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2596790-A1 | Pim kinase inhibitors and methods of their use | Novartis AG (CH) | 2013-05-29 | — | — | EP | disclosed |