Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 20/20 | 0.71 |
| ▸ | PIM1 | P11309 | 19/20 | 0.71 |
| ▸ | PIM3 | Q86V86 | 19/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13707763 | 0.91 | PIM2 (0.77) | PIM2PIM1PIM3 | |
| SCHEMBL4132795 | 0.88 | PIM1 (0.83) | PIM2PIM1PIM3 | |
| SCHEMBL4128482 | 0.83 | PIM1 (1.00) | PIM2PIM1PIM3 | |
| SCHEMBL4121015 | 0.82 | PIM1 (0.82) | PIM2PIM1PIM3 | |
| SCHEMBL4134079 | 0.80 | PIM1 (0.83) | PIM2PIM1PIM3 | |
| SCHEMBL4132781 | 0.80 | PIM1 (0.83) | PIM2PIM1PIM3 | |
| SCHEMBL17115533 | 0.80 | PIM1 (0.77) | PIM2PIM1PIM3 | |
| SCHEMBL17115557 | 0.80 | PIM1 (0.77) | PIM2PIM1PIM3 | |
| SCHEMBL17115551 | 0.79 | PIM1 (0.78) | PIM2PIM1PIM3 | |
| SCHEMBL4122514 | 0.78 | PIM2 (1.00) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2596790-A1 | Pim kinase inhibitors and methods of their use | Novartis AG (CH) | 2013-05-29 | — | — | EP | disclosed |