Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 10/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.57 |
| ▸ | INSR | P06213 | 4/20 | 0.57 |
| ▸ | IGF1R | P08069 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | STK25 | O00506 | 1/20 | 0.55 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | CASK | O14936 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.55 |
| ▸ | MUSK | O15146 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912095 | 0.94 | EGFR (0.64) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL10209551 | 0.91 | ZAP70 (0.61) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12729041 | 0.91 | ZAP70 (0.61) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12781068 | 0.91 | ZAP70 (0.71) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12780213 | 0.90 | ZAP70 (0.74) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12893014 | 0.90 | ZAP70 (0.71) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12729031 | 0.89 | ZAP70 (0.75) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12729023 | 0.88 | ZAP70 (0.71) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12781283 | 0.86 | ALK (0.71) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL10208645 | 0.85 | ALK (0.68) | ZAP70ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287156-B1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-05-29 | — | — | EP | disclosed |