Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 13/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780105 | 0.89 | ALK (0.69) | ALKINSRROS1 | |
| SCHEMBL12892748 | 0.89 | ALK (0.64) | ALKINSRROS1 | |
| SCHEMBL12892746 | 0.81 | ALK (0.66) | PTK2ALKINSRROS1 | |
| SCHEMBL1911962 | 0.81 | ALK (0.66) | PTK2ALKINSRROS1 | |
| SCHEMBL1912105 | 0.81 | ALK (0.66) | PTK2ALKINSRROS1 | |
| SCHEMBL12780125 | 0.81 | ALK (0.59) | ALKINSRROS1 | |
| SCHEMBL12781682 | 0.80 | ZAP70 (0.65) | ALKINSRROS1 | |
| SCHEMBL12892741 | 0.80 | ZAP70 (0.65) | ALKINSRROS1 | |
| SCHEMBL12781187 | 0.80 | ALK (0.62) | ALKINSRROS1 | |
| SCHEMBL1912088 | 0.80 | ALK (0.54) | ALKINSRROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287156-B1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-05-29 | — | — | EP | disclosed |