Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.73 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.71 |
| ▸ | JAK2 | O60674 | 1/20 | 0.71 |
| ▸ | LCK | P06239 | 1/20 | 0.71 |
| ▸ | LYN | P07948 | 1/20 | 0.71 |
| ▸ | JAK1 | P23458 | 1/20 | 0.71 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.71 |
| ▸ | JAK3 | P52333 | 1/20 | 0.71 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.71 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16202637 | 0.90 | SYK (0.74) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14975885 | 0.85 | SYK (0.82) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1354262 | 0.84 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14975783 | 0.84 | SYK (0.82) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1312033 | 0.84 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| Hydrochloric Acid SCHEMBL30189541 | 0.83 | SYK (0.98) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14975680 | 0.81 | SYK (0.78) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1355098 | 0.81 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14976570 | 0.81 | SYK (0.81) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14981658 | 0.80 | SYK (0.71) | SYKMAPK3MAPK1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |