Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | AKT2 | P31751 | 4/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14976303 | 0.97 | AKT1 (0.63) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14332890 | 0.85 | AKT1 (0.72) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14975748 | 0.84 | AKT1 (0.71) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14977088 | 0.84 | AKT1 (0.71) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14975701 | 0.84 | AKT1 (0.62) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14976354 | 0.84 | AKT1 (0.64) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14983744 | 0.83 | AKT1 (0.69) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL22244811 | 0.83 | CYP1A2 (0.66) | AKT1CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL14975704 | 0.82 | AKT1 (0.64) | AKT1CYP2C9CYP3A4CYP2D6AKT2 | |
| SCHEMBL14976262 | 0.81 | AKT1 (0.67) | AKT1CYP2C9CYP3A4CYP2D6AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078254-A1 | BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-05-30 | — | — | WO | disclosed |