Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.95 |
| ▸ | KDM6B | O15054 | 3/20 | 0.95 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.95 |
| ▸ | KDM4A | O75164 | 2/20 | 0.95 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.95 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.95 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.95 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.95 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.95 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977509 | 0.97 | KDM4E (1.00) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14977508 | 0.97 | KDM4E (1.00) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985097 | 0.96 | KDM6B (0.98) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985023 | 0.96 | KDM6B (0.98) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985084 | 0.96 | KDM6B (0.98) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985082 | 0.96 | KDM6B (0.98) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985114 | 0.91 | KDM4E (0.80) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14981874 | 0.89 | KDM4E (0.84) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985111 | 0.88 | KDM4E (0.83) | KDM4EKDM6BKDM4CKDM4AEGLN2 | |
| SCHEMBL14985098 | 0.88 | KDM4E (0.83) | KDM4EKDM6BKDM4CKDM4AEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735622-B2 | Histone demethylase inhibitors and methods for using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-05-27 | — | — | US | disclosed |
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | The Regents of the University of Colorado, a body corporated (US) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137720-A1 | HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME | KDM1A, KDM3A, KDM7A | KDM4E 13/4885KDM6B 15/4885KDM4C 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.