Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | SYK | P43405 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14955867 | 0.81 | BTK (0.54) | BTKLCKJAK3SYKIRAK4 | |
| SCHEMBL14955864 | 0.81 | BTK (0.54) | BTKLCKJAK3SYKIRAK4 | |
| SCHEMBL14956359 | 0.81 | BTK (0.50) | BTKLCKJAK3SYKKCNH2 | |
| SCHEMBL14956356 | 0.81 | BTK (0.50) | BTKLCKJAK3SYKKCNH2 | |
| SCHEMBL14955990 | 0.81 | BTK (0.54) | BTKLCKJAK3SYKKCNH2 | |
| SCHEMBL14956457 | 0.80 | BTK (0.53) | BTKLCKJAK3SYKIRAK4 | |
| SCHEMBL14956455 | 0.80 | BTK (0.53) | BTKLCKJAK3SYKIRAK4 | |
| SCHEMBL14976147 | 0.80 | BTK (0.53) | BTKLCKJAK3SYKKCNH2 | |
| SCHEMBL14955956 | 0.79 | BTK (0.51) | BTKLCKJAK3SYK | |
| SCHEMBL14955954 | 0.79 | BTK (0.51) | BTKLCKJAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |