Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14955585 | 0.90 | IRAK4 (0.49) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL14955719 | 0.87 | IRAK4 (0.49) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL14956091 | 0.84 | IRAK4 (0.51) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL14955680 | 0.81 | IRAK4 (0.53) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL16743372 | 0.78 | SYK (0.50) | SYKKCNH2 | |
| SCHEMBL14955582 | 0.74 | IRAK4 (0.49) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL14956072 | 0.73 | IRAK4 (0.58) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL14956759 | 0.73 | IRAK4 (0.53) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL14956101 | 0.73 | IRAK4 (0.52) | CDC7PLK4CHEK1PDPK1DAPK3 | |
| SCHEMBL16743352 | 0.72 | SYK (0.52) | SYKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |